Sir James Robert George Graham, 2nd Baronet GCB PC (1 June 1792 - 25 October 1861) was a British statesman, who notably served as Home Secretary and First Lord of the Admiralty. He was the eldest son of Sir James Graham, 1st Baronet, by Lady Catherine, eldest daughter of the 7th Earl of Galloway.

In 1819, he married Fanny Callander, youngest daughter of Sir James Campbell of Craigforth and Ardkinglas Castle. Sir James was created Doctor of Laws at the University of Cambridge in 1835, was Lord Rector of the University of Glasgow, 1840. He was First Lord of the Admiralty from 1830 to 1834 when he resigned on account of the government pressing for a reform of the Irish Church. He became Secretary of the Home Department from September 1841 to July 1846 and again First Lord of the Admiralty from December 1852 until February 1855.